January 14, 2022

In this bulletin, Alverno Laboratories provided important updates for healthcare providers. Firstly, they highlighted the potential for false reactive results on the RPR non-Treponemal Syphilis screen within 5 months of mRNA COVID-19 vaccination, advising careful interpretation in conjunction with patient history and risk factors. They also outlined two testing algorithms for Syphilis screening: the traditional RPR first approach and the reverse Treponemal antibody first strategy, with confirmatory testing following the initial screen assay. Secondly, they noted a correction regarding the postponement of updates for CBC pediatric ranges and manual differential reference range to April 2022, previously mentioned in a client bulletin. These updates aim to ensure accurate testing and interpretation, particularly in light of evolving clinical contexts.